Research
Hillman Laboratory
To learn more about current laboratory research on GCT:
https://www.mdanderson.org/research/departments-labs-institutes/labs/hillman-laboratory.html
Granulosa Cell Tumor Molecular Mechanisms: The lab has pioneered the development of numerous granulosa cell tumor models including isogenic cell culture lines, xenograft animal models, and high-fidelity genetically-engineering animal models. Using these models, members of the lab apply cutting-edge multi-omic approaches to understanding the molecular and gene regulatory changes that underpin the development and recurrence of this rare disease.
Granulosa Cell Tumor Therapeutics: Members of the laboratory use high-throughput drug screening platforms and functional genomics to discover novel therapeutic vulnerabilities in granulosa cell tumors. These discoveries are in turn being used to develop and launch new early-phase clinical trials in the treatment of ovarian granulosa cell tumors.
Granulosa Cell Organoid Biobank
The Hillman lab maintains an active research protocol for the collection and derivation of Granulosa Cell Tumor Organoids from tumor donated by patients affected by this disease who have surgery at MD Anderson Cancer Center. These organoids are grown in the laboratory and used for experiments to discovery new treatments for this disease and to better understand its causes.